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July 23, 2026Epidemiology and InfectionOpen Access

Impact of 23-valent pneumococcal polysaccharide vaccination on non-invasive pneumococcal pneumonia: a regression discontinuity analysis

Femke S Vernooij F Annabel Niessen Anneke Steens Mirjam Knol H E de Melker Jan van de Kassteele Cornelis H. van Werkhoven PPV23-NIPP study group

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Key Points

The study aims to assess the impact of the 23-valent pneumococcal polysaccharide vaccine on the incidence of non-invasive pneumococcal pneumonia.
Regression discontinuity analysis utilized to evaluate the vaccine's impact
Statistical techniques were applied to analyze pneumonia cases and vaccination status.
Vaccination resulted in a statistically significant reduction in non-invasive pneumococcal pneumonia incidence
Significant implications for public health strategy and vaccination recommendations.

Implication

Regression discontinuity analysis reveals vaccination effects on pneumonia incidence, suggesting a vital intervention strategy.

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Cite This Study

Vernooij et al. (2026) studied this question.

synapsesocial.com/papers/6a65a6b5d3aea3239cd77d52 https://doi.org/10.1017/s0950268826101952

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Persistence of antibody to 23-valent pneumococcal polysaccharide vaccine: a 5-year prospective follow-up cohort study2024 · 3 citations
2ASSOCIATION BETWEEN INTRODUCTION OF 13-VALENT PNEUMOCOCCAL CONJUGATE VACCINE AND BURDEN OF HOSPITALIZED ADULT PNEUMOCOCCAL DISEASE IN TAIWAN – A RETROSPECTIVE DATABASE STUDYCohort Study · 2026
3Follow-Up Study of Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine Against All-Type and Serotype-Specific Invasive Pneumococcal Disease, Denmark2024 · 4 citations
4Effectiveness of the 23-Valent Pneumococcal Polysaccharide Vaccine (PPV23) in Preventing Community-Acquired Pneumonia in Adults: A Population-Based Cohort Study2024 · 4 citations
5Insights into the heterogeneity of pneumococcal polysaccharide vaccine immunogenicity in older adultsOriginal Research · 2026

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Safety and Immunogenicity of a 23-Valent Pneumococcal Polysaccharide Vaccine (PPSV23) in Chinese Children, Adults and the Elderly: A Phase 4, Randomized, Double-Blind, Active-Controlled Clinical Trial2025
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Protection and Duration of 23-Valent Pneumococcal Polysaccharide Vaccine Against Hospitalization for Community-Acquired Pneumonia in Older Adults with Low Vaccination Coverage: A Multicenter Matched Case–Control Study in China2026

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