Association of the cardiometabolic index and depressive symptoms with cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0–3: A prospective cohort study

Figures

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  Fig. 1. Study participant flow diagram. CKM, cardiovascular-kidney-metabolic; CVD, Cardiovascular Disease; CMI, cardiometabolic index.

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  Fig. 2. (A) Kaplan–Meier analysis for CVD was based on the CMI quartiles in a population with CKM syndrome stages 0–3. (B) Kaplan–Meier analysis for CVD was based on the dichotomized cumulative CMI in a population with CKM syndrome stages 0–3.

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  Fig. 3. Non-Linear Relationship Between CMI, CumCMI and CVD Risk in a population with CKM syndrome stages 0–3; A: CMI and CVD (Crude Modle); B: CMI and CVD (Adjusted Modle for Age, Gender, BMI, Hypertension, Diabetes); C: CumCMI and CVD Risk (Crude Modle); D: CumCMI and CVD Risk (Adjusted Modle for Age, Gender, BMI, Hypertension, Diabetes). Abbreviations: CKM, cardiovascular-kidney-metabolic; BMI, body mass index; CMI, cardiometabolic index; CVD, Cardiovascular Disease; CumCMI, Cumulative cardiometabolic index.

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  Fig. 4. Kaplan–Meier analysis for CVD was based on the synergistic effects of CMI and depressive symptoms in a population with CKM syndrome stages 0–3. Abbreviations: CMI, cardiometabolic index; CVD, Cardiovascular Disease; CKM, cardiovascular-kidney-metabolic; CumCMI, Cumulative cardiometabolic index.

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  Fig. 5. ROC curves comparing the predictive efficacy of the CMI, depressive symptoms, and their synergistic effects for CVD in patients with CKM syndrome stages 0–3 over follow-up years. Abbreviations: ROC, receiver operating characteristic; AUC, Area Under the Curve; CMI, cardiometabolic index; CVD, Cardiovascular Disease; CKM, cardiovascular-kidney-metabolic.

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  Fig. 6. Forest plot of subgroup analyses for the combined effect of high CumCMI and depressive symptoms on CVD risk in CKM stages 0–3.