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July 26, 2026The Journal of Biochemistry

Lysosomes and Supersulfides: Emerging Links in Cellular Metabolism and Homeostasis

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Authors

NSNatsumi SakataTATakaaki AkaikeHMHozumi Motohashi

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Overview

Review summarizes lysosome and supersulfide interactions in cellular homeostasis, suggesting a new regulatory axis.

Key Points

  • This review aims to explore the connections between lysosomes and supersulfides in cellular metabolism and homeostasis.
  • Summarized recent findings in supersulfide biology and lysosomal regulation.
  • Discussed functional interactions between lysosomal activity and supersulfide metabolism.
  • Lysosomes play a crucial role in the metabolism of supersulfides via acidification and cysteine metabolism.
  • Supersulfides influence lysosomal function and modulate inflammatory responses.
  • Proposed a new concept of the lysosome-supersulfide axis in regulating cellular homeostasis.

Cite This Study

Sakata et al. (2026) studied this question.

synapsesocial.com/papers/6a65a6f2d3aea3239cd78090https://doi.org/10.1093/jb/mvag058
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