Key result
Hypokalemia induced molecular phenotypic alterations consistent with cardiac hypertrophy in vitro and exacerbated cardiac growth following acute aortic constriction in an in vivo rat model.
Why the study?
Does hypokalemia induce molecular phenotypic alterations consistent with cardiac hypertrophy in preclinical models?
Population
Neonatal myocytes in culture and rat models
Comparison
Reductions in extracellular potassium… vs Control media and control diet
Design
Preclinical
Follow-up
3-5 weeks (in vivo)
Authors
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Does not support altering potassium management in renal failure; leaves open in vivo translation of neonatal myocyte findings.
Does hypokalemia induce molecular phenotypic alterations consistent with cardiac hypertrophy in preclinical models?
Hypokalemia may produce molecular phenotypic alterations consistent with cardiac hypertrophy and contribute to hypertrophy in response to pressure overload.
Xie et al. (2000) studied Cardiac hypertrophy. Hypokalemia / dietary potassium restriction vs. Control diet / normal potassium media was evaluated on Hypertrophic response and cardiac growth. Hypokalemia induced molecular phenotypic alterations consistent with cardiac hypertrophy in vitro and exacerbated cardiac growth following acute aortic constriction in an in vivo rat model.
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