Key result
Total ischemia of 120 minutes or longer in canine myocardium resulted in progressive loss of vinculin staining, correlating with subsarcolemmal blebs and plasma membrane breaks.
Population
Canine heart model (in vitro)
Comparison
Varying periods of total in vitro ischemia vs Control myocardium
Design
Preclinical
Authors
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Cytoskeletal vinculin redistribution may contribute to ischemic membrane injury; leaves open whether targeting it alters clinical outcomes.
Prolonged myocardial ischemia (≥120 minutes) leads to progressive loss of vinculin and subsequent plasma membrane disruption in a canine model.
Steenbergen et al. (1987) studied Myocardial ischemia. Total in vitro ischemia vs. Control myocardium was evaluated on Changes in vinculin immunofluorescence staining and membrane disruption. Total ischemia of 120 minutes or longer in canine myocardium resulted in progressive loss of vinculin staining, correlating with subsarcolemmal blebs and plasma membrane breaks.
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