Key result
Fluid-percussion brain injury induced a maximal 500-fold increase in epinephrine and 100-fold increase in norepinephrine at a 3.0-atmosphere injury level.
Effect estimate: 500-fold increase for E, 100-fold increase for NE
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No immediate clinical implications from feline TBI model; leaves open human mechanistic and interventional studies.
Rosner et al. (1984) studied Mechanical brain injury (n=16). Fluid-percussion brain injury vs. Baseline was evaluated on Catecholamine release (epinephrine and norepinephrine) (500-fold increase for E, 100-fold increase for NE). Fluid-percussion brain injury induced a maximal 500-fold increase in epinephrine and 100-fold increase in norepinephrine at a 3.0-atmosphere injury level.
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