Piezo1: Molecular mechanisms and therapeutic potential in ligamentum flavum hypertrophy and lumbar spinal stenosis

Ligamentum flavum hypertrophy (LFH) is a major cause of lumbar spinal stenosis, which can lead to progressive lower back pain and impaired nerve function, resulting in a significant global disease burden. At present, the pathological mechanism of LFH has not been fully elucidated, and effective treatment methods are lacking. Piezo1 is a channel activated by mechanical stress. It is activated under mechanical stress and participates in various physiological and pathological processes related to oxidative stress, including inflammation, fibrosis, ferroptosis, vascular remodeling and pyrolysis. However, its role in the development of LFH is still unclear. In this review, we examined the role of Piezo1 in oxidative stress, inflammation, fibrosis, ferroptosis, vascular remodeling, cell pyroptosis, as well as its potential connection with LFH. These findings provide new ideas for the treatment of the LFH.