SGLT2 inhibitor use at discharge was associated with a lower risk of cardiac death or heart failure rehospitalization at 1 year (HR 0.76; P=0.045), particularly in patients with frailty.
Observational (n=5,579)
Yes
Does SGLT2 inhibitor use at discharge reduce cardiac death or heart failure rehospitalization in patients hospitalized for acute heart failure, particularly those with frailty?
SGLT2 inhibitor use at discharge in patients with acute heart failure is associated with improved 1-year outcomes, particularly in frail patients, without causing nutritional harm.
Hazard Ratio: 0.76
p-value: p=0.045
Background SGLT2 (sodium–glucose cotransporter‐2) inhibitors (SGLT2is) improve outcomes in heart failure (HF), but evidence in patients with frailty and acute HF (AHF) is limited. This study investigated the association between SGLT2i use at discharge and outcomes in patients with AHF, with a focus on frailty. Methods We analyzed 5579 patients hospitalized for AHF enrolled between 2018 and 2024 in the prospective WET‐HF2 (West Tokyo Heart Failure 2) registry in Japan (age 79 years, 43% women, body mass index 23.1, 23% ischemic cause, left ventricular ejection fraction 45%, 24% SGLT2is at discharge). Frailty was assessed using the Clinical Frailty Scale (≥4; 63%), and complementary analyses were performed using frailty‐related factors (low body mass index, reduced activities of daily living, malnutrition, and dementia). The primary outcome was a composite of cardiac death or HF rehospitalization within 1 year, which occurred in 766 patients (18%). A propensity score was calculated using variables associated with SGLT2i prescription. Results After propensity score–based inverse probability of treatment weighting adjustment, SGLT2i use was associated with a lower risk of the primary outcome (hazard ratio HR, 0.76, P =0.045). This association was more pronounced in patients with frailty (HR, 0.59, P =0.005), but not in patients without frailty (HR, 1.18; P interaction =0.010). Analyses using frailty‐related factors yielded similar patterns. At 1 year, SGLT2i use at discharge was not associated with deterioration in body mass index or nutritional status. Conclusions In this observational registry, SGLT2i use at discharge was associated with improved outcomes in patients with AHF, particularly those with frailty, without evidence of nutritional harm. These findings support the potential safety of SGLT2is in patients with frailty and AHF.
Naito et al. (Sat,) conducted a observational in Acute Heart Failure (n=5,579). SGLT2 inhibitors vs. No SGLT2 inhibitor use at discharge was evaluated on Composite of cardiac death or heart failure rehospitalization within 1 year (HR 0.76, p=0.045). SGLT2 inhibitor use at discharge was associated with a lower risk of cardiac death or heart failure rehospitalization at 1 year (HR 0.76; P=0.045), particularly in patients with frailty.