Randomized trial explores pH-responsive drug delivery in hydrogels, suggesting effective tissue engineering solutions.
Key Points
This research aims to develop a bioactive hydrogel that combines mechanical strength with antioxidant properties for potential tissue regeneration applications.
Fabricated κ-carrageenan–egg albumin hydrogel incorporating curcumin–Aloe vera composite via ionotropic gelation.
Characterized hydrogels using mechanical testing, FTIR, SEM, swelling analyses, and antioxidant assessment.
Evaluated in vitro cytocompatibility using the MTT assay over seven days.
The CUR–ALV composite enhanced hydrogel mechanical performance and cell viability, achieving ~67% antioxidant activity.
Hydrogel exhibited pH-responsive curcumin release with a maximum of ~80% at pH 8.5, influenced by erosion.
High hydrophilicity and controlled biodegradation under physiological conditions were observed.