Recurrent episodes of hypoglycemia as an initial presentation of pituitary stalk interruption syndrome: A case report

Pituitary stalk interruption syndrome is a rare, congenital endocrine disorder of hypopituitarism. It has highly variable clinical presentation depending on the extent and type of hormonal deficiency and age at presentation, with growth hormone deficiency being the most common manifestation. Growth hormone plays an important role in maintaining normal blood glucose levels during stress or fasting, by stimulating hepatic gluconeogenesis and lipolysis. Therefore, hypoglycemia should alert us to a possibility of growth hormone deficiency necessitating imaging and facilitating early diagnosis of pituitary stalk interruption syndrome.