Key result
A 62-year-old woman developed new-onset atrial fibrillation requiring intensive care and cardioversion shortly after initiating tirzepatide, which did not recur after discontinuation.
Why the study?
Although tirzepatide is generally considered cardiometabolically beneficial, rare cardiac rhythm disturbances may occur.
Case Report (n=1)
This case report suggests a potential association between tirzepatide initiation and new-onset atrial fibrillation, highlighting the need for clinical vigilance for arrhythmias with novel incretin-based therapies.
May signal rare tirzepatide-associated AF; hypothesis-generating and should not yet change practice.
Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, is increasingly prescribed for the treatment of type 2 diabetes and obesity. Although it is generally considered cardiometabolically beneficial, rare cardiac rhythm disturbances may occur. We describe a 62-year-old woman without a prior history of cardiovascular disease who developed new-onset atrial fibrillation (AF) shortly after initiating tirzepatide. She presented with palpitations, hypotension, and rapid ventricular response requiring intensive care, rate control, anticoagulation, and electrical cardioversion. A thorough examination showed that there was no structural heart disease, electrolyte imbalance, or endocrine disorder. Following discontinuation of tirzepatide, AF did not recur during follow-up. This case highlights the importance of clinical vigilance for arrhythmias when initiating novel incretin-based therapies.
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Purvez et al. (2025) conducted a case report in New-onset atrial fibrillation (n=1). Tirzepatide was evaluated on New-onset atrial fibrillation. A 62-year-old woman developed new-onset atrial fibrillation requiring intensive care and cardioversion shortly after initiating tirzepatide, which did not recur after discontinuation.
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