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July 28, 2026Gastrointestinal Oncology Management and CareOpen Access

Gastrointestinal stromal tumors (GIST): a contemporary review

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Authors

SWSarah WilliamsJPJavier PozasANAndrea Napolitano

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Overview

Narrative review examines molecular biology and management of gastrointestinal stromal tumors, suggesting improved strategies for treatment.

Key Points

  • To summarize current evidence on the molecular biology and management of gastrointestinal stromal tumors (GISTs).
  • Narrative review of molecular biology, pathology, and management of localized and advanced GIST.
  • Emphasis on genotype-directed therapy and patient stratification based on molecular characteristics.
  • Discussion of surgical, adjuvant, and neoadjuvant therapies for GIST.
  • Surgical resection is crucial for localized GIST treatment.
  • Adjuvant imatinib improves survival in high-risk, imatinib-sensitive disease, with three years of therapy as standard.
  • Sequential TKI therapy significantly enhances outcomes for advanced GISTs, influenced by molecular subtype.

Cite This Study

Williams et al. (2026) studied this question.

synapsesocial.com/papers/6a6850eb2845b684d16effe1https://doi.org/10.1080/29937817.2026.2704886
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