Case report reveals airway toxicity in infant treated with MEK inhibitor, suggesting clinical vigilance.
An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.
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Drozdowski‐Nuccio et al. (2026) studied this question.
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