Case series presents clinical data on hereditary leiomyomatosis and renal cell carcinoma in affected families, indicating significant health implications.
Case presentationsWe present the clinical data of six Chinese individuals from four affected families with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) in Hong Kong (Table ).All female probands (Cases 1, 2 and 5) presented with menorrhagia and severe anaemia requiring intravenous iron therapy (online supplementary Table 1).The mean age at presentation was 28 years (range, 21-33).On examination, all had a palpable pelvic mass and imaging revealed a uterine smooth muscle tumour (USMT).All underwent uterine myomectomy at a mean age of 28.7 years (range, 23-33).Two were subsequently diagnosed with leiomyoma and one had a smooth muscle tumour
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Cheung et al. (2026) studied this question.
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