In vitro/in silico ASSESSMENT OF Symphytum officinale L. EXTRACT ON A549 CELLS; NEUROKININ-1 RECEPTOR-MEDIATED INTERACTIONS OF MALAXINIC ACID AND GLOBOIDNAN A

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This research aims to evaluate the effects of Symphytum officinale extracts on lung cancer cell proliferation and their interactions with specific receptors.
Determined phenolic content and antioxidant capacity of Symphytum officinale extracts.
Assessed the effects on A549 lung cancer cells using the MTT assay.
Quantified levels of substance P, VEGF, and IL-6 by ELISA; conducted molecular docking of malaxinic acid and globoidnan A.
S. officinale extract significantly reduced the viability and proliferation of A549 lung cancer cells.
ELISA assays showed significant reductions in substance P and vascular endothelial growth factor levels (exact metrics not provided).
Molecular docking indicated potential interactions of malaxinic acid and globoidnan A with relevant receptors.

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Demonstrates the effects of Symphytum officinale extract on A549 lung cancer cells, suggesting potential therapeutic benefits.

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Akçit et al. (2026) studied this question.

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