Key result
Cross-linking decellularized myocardial hydrogels enhances stiffness and slows degradation while preserving catheter injectability.
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Injectable materials offer the potential for minimally invasive therapy for myocardial infarction (MI), either as an acellular scaffold or as a cell delivery vehicle. A recently developed myocardial matrix hydrogel, derived from decellularized porcine ventricular tissue, has the potential to aid in cardiac repair following an MI. Herein, we set out to study the effects of cross-linking on the cardiac hydrogel stiffness, degradation properties, cellular migration, and catheter injectability in vitro. Cross-linking increased stiffness, while slowing degradation and cellular migration through the gels. Additionally, the cross-linked material was pushed through a clinically relevant catheter. These results demonstrate that the material properties of myocardial matrix can be tuned via cross-linking, while maintaining appropriate viscosity for catheter injectability.
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Singelyn et al. (2011) studied Myocardial infarction. Cross-linking of decellularized myocardial matrix hydrogel was evaluated on Cardiac hydrogel stiffness, degradation properties, cellular migration, and catheter injectability in vitro. Cross-linking of a decellularized myocardial matrix hydrogel increased stiffness and slowed degradation in vitro, while maintaining appropriate viscosity for catheter injectability.
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