Metabolic Effects of Tetracycline

Editorials1 March 1963Metabolic Effects of TetracyclineMARK H. LEPPER, M.D.MARK H. LEPPER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-3-553 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn formulating his theories on the mechanism of chemotherapeutic effects, Ehrlich was greatly influenced by the evidence in his studies on dyes of the specificity of the immune reaction and the specificity of the tissue in the host. The dominant thought that evolved was that chemically defined substances could be found which would have a selective deleterious effect on the parasite. He originated the famous "magic bullet" metaphor for destruction of the parasite without injury to the tissue cell. Although the ideal result would have been complete destruction of the invader and complete lack of effect on the host, Ehrlich...References1. BATEMANBARBERIOBRICEKLOPPPIERPONT JCJRPCTH: Fatal complications of intensive antibiotic therapy in patients with neoplastic disease. Arch. Intern. Med. (Chicago) 90: 763, 1952. CrossrefGoogle Scholar2. LEPPER MH: In Communicable and Infectious Diseases, ed by Top, F. M., The C. V. Mosby Company, St. Louis, 1960, p. 137. Google Scholar3. GABUZDAGOCKEJACKSONGRIGSBYLOVEFINLAND JJTMGGMEBDM: Some effects of antibiotics on nutrition in man including studies of the bacterial flora of the feces. Arch. Intern. Med. (Chicago) 101: 476, 1958. CrossrefGoogle Scholar4. FALOON WW: Metabolic and histologic studies in patients with and without liver disease receiving chloramphenicol and oxytetracycline. J. Lab. Clin. Med. 44: 75, 1954. MedlineGoogle Scholar5. FALOONDOWNSDUGGANPRIOR WWJJKJT: Nitrogen and electrolyte metabolism and hepatic function and histology in patients receiving tetracycline. Amer. J. Med. Sci. 233: 563, 1957. CrossrefMedlineGoogle Scholar6. FALOONNOLLPRIOR WWJWJT: Nitrogen metabolism and liver histology during Aureomycin administration in patients with hepatic disease. J. Lab. Clin. Med. 41: 596, 1953. MedlineGoogle Scholar7. BATEMANKLOPPSAMSON JCCTR: Effect of nephrectomy or azotemia associated with parenteral antibiotic administration, in Antibiotics Annual 1953-1954, Medical Encyclopedia, Inc., New York, 1954, p. 531-534. Google Scholar8. NESBITADCOCKBAUMOWEN RMJWCCR: Clinical experience with Terramycin in the treatment of refractory urinary tract infections. J. Urol. 65: 336, 1951. CrossrefMedlineGoogle Scholar9. WOMACKJACKSONGOCKEKASSHAIGHTFINLAND CRGGTMEHTHM: Terramycin therapy of urinary tract infections. Arch. Intern. Med. (Chicago), 89: 240, 1952. CrossrefGoogle Scholar10. FARHATSCHELHARTMUSSELMAN SMDLMM: Clinical observations on toxicity of tetracyclines in man with experimental studies in animals, in Antibiotics Annual, 1957-1958, Medical Encyclopedia, Inc., New York, 1958, p. 416-429. Google Scholar11. LIEBERLEFEVRE CSA: Ammonia as a source of gastric hypoacidity in patients with uremia. J. Clin. Invest. 38: 1271, 1959. CrossrefMedlineGoogle Scholar12. HOODBENGTSSONISAKSSONKOLLBERGRADBERG BUBSC: Intensive treatment of chronic pyelonephritis. Acta Med. Scand. 166: 205, 1960. CrossrefMedlineGoogle Scholar13. LUCKEYREYNIERSGYÖRGYFORBES TDJAPM: Germ free animals and liver necrosis. Ann. NY Acad. Sci. 57: 932, 1954. CrossrefMedlineGoogle Scholar14. BRAINERTBRUYNMEIKLEJOHNO'GARA HDHBGL: Studies on the clinical pharmacology of Aureomycin. Antibiot. Chemother. (NY) 1: 447, 1951. MedlineGoogle Scholar15. ORENTREICHHARBERTROMOVITCH NLCTA: Photosensitivity and photo-oncholysis due to demethyl chlortetracycline. Arch. Derm. (Chicago) 83: 730, 1961. CrossrefMedlineGoogle Scholar16. MALEKKOLEZAK PJF: Further studies on fluorescence of tetracycline analogues in pathologically changed tissues, in Antimicrobial Agents Annual 1960, Plenum Press, New York, 1961, p. 206. Google Scholar17. COHLANBEVELANDERBROSS SQGS: Effect of tetracycline on bone growth in the premature infant, in Antimicrobial Agents and Chemotherapy 1961, Braun-Brumfield Inc., Ann Arbor, Michigan, 1962, p. 340. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Preventive Medicine University of Illinois College of Medicine Chicago 12, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Pharmacologic Management of the Syndrome of Inappropriate Secretion of Antidiuretic HormoneCorrection of Antidiuresis by DemeclocyclineEffects of tetracycline on pancreatic protein synthesis and secretion in pigeonsTetracycline in the treatment of rheumatoid arthritis. A double blind controlled studyDer Einfluß von anabolen Hormonen und von Diät auf den myokardialen Gehalt an energiereichen Phosphaten während der InfarktheilungPuzzling HematuriaComplications of tetracycline therapyEnvironment and the Kidney 1 March 1963Volume 58, Issue 3Page: 553-556KeywordsSpecificityTetracyclines Issue Published: 1 March 1963 PDF downloadLoading ...