Key result
Heart rate reduction with ivabradine protects the endothelium during the early phase of atherosclerosis in ApoE-deficient mice, potentially by activating Notch signaling.
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mice. Activation of the Notch signalling could be part of the mechanism underlying this protection.
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Aquila et al. (2018) studied this question. Heart rate reduction with ivabradine protects the endothelium during the early phase of atherosclerosis in ApoE-deficient mice, potentially by activating Notch signaling.
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