Key result
Biologics used for inflammatory arthritis and vasculitides, including TNF-alpha, IL-6, IL-1 blockades, and anti-CD20, have both beneficial and deleterious effects on the cardiovascular system.
Why the study?
What are the cardiovascular effects of biologic therapies in patients with chronic inflammatory diseases?
What are the cardiovascular effects of biologic therapies in patients with chronic inflammatory diseases?
Biologic therapies for chronic inflammatory diseases have both beneficial and deleterious effects on cardiovascular conditions such as heart failure, myocardial infarction, and atherosclerosis.
Warrants individualized CV risk assessment with biologics; leaves open net effects of specific agents.
Patients with chronic inflammatory diseases such as rheumatoid arthritis have a higher risk of cardiovascular diseases and related mortality compared to the general population. This risk is first due to classical cardiovascular risk factors but also due to systemic inflammation which is independently involved, causing accelerated atherosclerosis, myocardial infarction, cerebrovascular disease and heart failure (HF). Pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 and IL-6 could be major actors on this pathophysiology. Biologics are effective specific treatments in the management of inflammatory rheumatic and systemic diseases. In this review, beneficial and deleterious effects on the heart and vessels of the biologics used in the management of inflammatory arthritis and vasculitides will be discussed, focusing on TNF-alpha, IL-6 and IL-1 blockades, and anti-CD20. Noninflammatory cardiac conditions, such as heart failure, myocardial infarction, and cardiovascular conditions such as atherosclerosis, as well as inflammatory diseases including vasculitides will be discussed.
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Roubille et al. (2013) conducted a review in Chronic inflammatory diseases (e.g., rheumatoid arthritis, vasculitides). Biologics (TNF-alpha, IL-6, IL-1 blockades, and anti-CD20) was evaluated. Biologics used for inflammatory arthritis and vasculitides, including TNF-alpha, IL-6, IL-1 blockades, and anti-CD20, have both beneficial and deleterious effects on the cardiovascular system.
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