Propranolol, Hypoglycemia, and Hypertensive Crisis

Letters1 May 1974Propranolol, Hypoglycemia, and Hypertensive CrisisRANDOLPH J. MCMURTRY, M.D., PH.D.RANDOLPH J. MCMURTRY, M.D., PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-5-669 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The use of beta-adrenergic blocking agents has been implicated in the development of hypoglycemia (1, 2) and peripheral arterial insufficiency (3) in certain individuals. I report a case in which hypertensive crisis and decreased peripheral blood flow developed in a hypertensive, insulin-dependent patient while she was on propranolol therapy, presumably because of insulin-induced hypoglycemia and endogenous catecholamine release.In November, 1973, a 50-year-old woman with insulin-dependent diabetes was placed on hydralazine, hydrochlorothiazide, and propranolol for her essential hypertension. Two days later the patient became confused during a speech clinic visit and, after administration of oral sugar, was...References1. KOTLERBERMANRUBENSTEIN MLA: Hypoglycaemia precipitated by propranolol. Lancet 2:1389-1390, 1966 CrossrefMedlineGoogle Scholar2. WRAYSUTCLIFFE RS: Propranolol-induced hypoglycaemia and myocardial infarction. Br Med J 2:592, 1972 CrossrefMedlineGoogle Scholar3. FROHLICHTARAZIDUSTAN ERH: Peripheral arterial insufficiency. A complication of beta-adrenergic blocking therapy. JAMA 208:2471-2472, 1969 CrossrefMedlineGoogle Scholar4. MORRELLI H: Propranolol. Ann Intern Med 78:913-917, 1973 LinkGoogle Scholar5. NIESSHAND AD: Hypertensive response to propranolol in a patient treated with methyl dopa—a proposed mechanism. Clin Pharmacol Ther 14:823-826, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Colorado Medical Center Denver, Colorado 80220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetogenic effects of cardioprotective drugsVital Signs, QT Prolongation, and Newly Diagnosed Cardiovascular Disease During Severe Hypoglycemia in Type 1 and Type 2 Diabetic PatientsUse of Beta Blockers in the Patient With DiabetesDANGEROUS AND COMMON DRUG INTERACTIONS IN PATIENTS WITH DIABETES MELLITUSβ-Adrenergic Blocking Agents in Patients With Diabetes—Friend and FoePharmacy UpdateSelection and Use of Beta-Blockers for Patients with Cardiovascular DiseaseDrug interactions in diabetic patientsAdrenalectomy abolishes antagonism of α-adrenoceptor-mediated hypotension by a β-blocker in conscious ratsReversal of α-adrenoceptor blockade by propranolol in isolated rat pulmonary arteryThe cardioselectivity of beta adrenoceptor antagonistsHypertension in the person with diabetesHypertensive CrisisHaemodynamic effects of atenolol, pindolol and propranolol during adrenaline infusion in manβ-Blockers and Glucose ControlUpdate of cardiovascular drug interactionsDisparate responses of blood pressure to adrenergic stimuli during beta blockadeThe effect of selective and non-selective beta-adrenoceptor blockade, and of naloxone infusion, on the hormonal mechanisms of recovery from insulin-induced hypoglycaemia in man.Treating Hypertension in the Patient with Diabetes MellitusA Trial of Metoprolol in Hypertensive Insulin-Dependent Diabetic PatientsEffect of Metoprolol and Alprenolol on the Metabolic, Hormonal, and Haemodynamic Response to Insulin-Induced Hypoglycaemia in Hypertensive, Insulin-Dependent DiabeticsHypoglycemia-Induced Hypertension in a Diabetic Patient on MetoprololALEXANDER M. M. SHEPHERD, M.D., Ph.D., MIN-SHUNG LIN, M.D., T. KENT KEETON, Ph.D.BLOOD PRESSURE AND PULSE RESPONSE TO INSULIN-INDUCED HYPOGLYCEMIA DURING NON-SELECTIVE AND SELECTIVE β-BLOCKADEHypoglycemiaHypertension following coronary artery bypass surgery. Role of preoperative propranolol therapy.β-Adrenoceptor blocking agents release catecholamines from rat adrenal medullaA Cardio-selective Beta Blocker (Metoprolol) in Hypertensive, Insulin-dependent DiabeticsBeta-Blocking Agents and Antidiabetic Drugsβ-adrenoceptor blocking drugs and hypertensionHypertension complicating treatment with beta-adrenergic blocking drugsSECONDARY HAEMORRHAGE AFTER RENAL TRANSPLANTATIONHYPOGLYCÆMIA IN PROPRANOLOL-TREATED DIALYSIS PATIENTSUnexpected pressor responses to propranolol in essential hypertensionAspects of Clonidine TherapyCLONIDINE WITHDRAWAL AND BLOCKADEDIAGNOSTIC X-RAYS IN PREGNANCYUses of PropranololPropranolol in orthostatic tachycardia 1 May 1974Volume 80, Issue 5Page: 669-670KeywordsBlood flowCatecholaminesHypertensionHypoglycemiaInsulin Issue Published: 1 May 1974 PDF downloadLoading ...