The electrochemical detection of NADH is of considerable interest because it is required as a cofactor in a large number of dehydrogenase-based biosensors. However, the presence of oxygenated functionalities on the electrode often causes fouling due to the adsorption of the oxidised form, NAD(+). Here we report an electroanalytical NADH sensor based on DMF-exfoliated graphene. The latter is shown to have a very low oxygen content, facilitating the exceptionally stable and sensitive detection of this important analyte.
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Keeley et al. (2011) studied this question.
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