Spontaneous eruptive keloid-like cutaneous lesions in a renal transplant patient: A form of nephrogenic systemic fibrosis?

This is a case report of a 63-year-old man post renal transplant who developed eruptive keloids, many of which developed with no history of previous trauma. Reports of spontaneous keloids are rare in the literature, and given his history of renal failure, we have considered a connection with nephrogenic systemic fibrosis (NSF). With no history of prior keloid formation, the patient developed a large number of lesions with a wide distribution, which then subsequently healed without keloid formation. Additionally, the lesions stained positive for CD68 and factor XIIIa, both of which are correlated with the lesions of NSF. However, the patient did not present with the classic clinical presentation of NSF, had no history of exposure to gadolinium, and staining for CD34 was negative. In conclusion, NSF is a relatively new disease, the details of which have yet to be clearly established. This case may represent a variant of NSF.