Key result
The eNOS T786C gene polymorphism significantly increased the risk of coronary heart disease in young individuals under a dominant genetic model (OR 2.25).
Why the study?
Reduced nitric oxide bioavailability and eNOS T786C gene polymorphism are risk factors for coronary heart disease, motivating an evaluation of their relationship in young people.
Is the eNOS T786C gene polymorphism associated with lower plasma nitric oxide levels and increased risk of coronary heart disease in young people?
Cross-Sectional (n=300)
No
Is the eNOS T786C gene polymorphism associated with lower plasma nitric oxide levels and increased risk of coronary heart disease in young people?
The eNOS T786C gene polymorphism is associated with reduced plasma nitric oxide levels and an increased risk of coronary heart disease in young individuals.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for eNOS T786C in young CHD; larger prospective studies needed before clinical adoption.
The study aims to examine plasma nitric oxide concentration and its relationship to T-786C gene polymorphism levels in the development of coronary heart disease in young people. Reduced nitric oxide (NO) bioavailability and endothelial nitric oxide synthase (eNOS) T786C gene polymorphism have been identified as risk factors for the development of coronary heart disease. This cross-sectional study was conducted in SRM Medical College Hospital and Research Centre on 200 angiographically proven CHD subjects attending the Department of Cardiology and medicine and 100 controls from MHC in the age group of ≤ 45 years. Overnight fasting plasma samples were obtained to evaluate lipid profile and nitric oxide by Griess reaction in UV spectrophotometry utilizing the ELISA technique. Polymerase Chain Reaction and Restricted fragment length polymerase amplify the eNOS gene T-786C. As a result, NO levels in plasma were significantly lower in CHD patients than in controls. In addition, C allele carriers of the eNOS T786C polymorphism showed significantly lower mean plasma NO levels than T allele carriers (P < 0.001). Our findings suggest that a lower plasma NO level is related to an increased risk of CHD. Furthermore, the eNOS T786C polymorphism is a significant risk factor for CHD development by lowering NO levels in the plasma. However, the eNOS T786C polymorphism influences the severity of CHD.
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Jaishankar et al. (2022) conducted a cross-sectional in Coronary Heart Disease (n=300). eNOS T786C gene polymorphism (CC + TC genotypes) vs. Wild type TT genotype was evaluated on Risk of coronary heart disease (dominant genetic model) (OR 2.25, 95% CI 1.33-4.14, p=0.003). The eNOS T786C gene polymorphism significantly increased the risk of coronary heart disease in young individuals under a dominant genetic model (OR 2.25).
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