Key result
Ultrasound measurement of carotid plaque burden is a strong predictor of cardiovascular risk, proving much stronger than intima-media thickness for representing true atherosclerosis.
Ultrasound measurement of carotid plaque burden is a strong predictor of cardiovascular risk and is useful for studying genetics and novel risk factors.
Ultrasound methods are useful in stroke prevention in several ways. Measurement of carotid plaque burden, as either total plaque area (TPA) or total plaque volume (TPV) are strong predictors of cardiovascular risk: much stronger than intima-media thickness, which does not represent true atherosclerosis, but a biologically and genetically distinct phenotype. Measurement of plaque burden is also useful for the study of genetics, and of new risk factors such as toxic products of the intestinal microbiome.
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J. David Spence (2020) conducted a review in Stroke prevention and cardiovascular risk. Ultrasound measurement of carotid plaque burden (TPA or TPV) vs. Intima-media thickness was evaluated. Ultrasound measurement of carotid plaque burden is a strong predictor of cardiovascular risk, proving much stronger than intima-media thickness for representing true atherosclerosis.
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