Why the study?
Does high-dose atorvastatin affect tendon-bone interface healing and fatty infiltration following rotator cuff repair in a rat model?
Population
20 Sprague-Dawley rats undergoing rotator cuff repair surgery on both shoulders
Design
Preclinical
Follow-up
4 weeks
Key result
High-dose atorvastatin did not impair histologic and biomechanical healing of the tendon-bone interface and significantly inhibited the expression of the muscle atrophy marker MuRF-1 (P < .001).
Authors
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May support statin continuation around rotator cuff repair; leaves open human translation.
Does high-dose atorvastatin affect tendon-bone interface healing and fatty infiltration following rotator cuff repair in a rat model?
High-dose atorvastatin does not negatively affect tendon-bone interface healing or muscle recovery following rotator cuff repair in a rat model, supporting its continued use in patients requiring statin therapy.
Yoon et al. (2025) studied Rotator cuff repair (n=20). High-dose atorvastatin vs. Control was evaluated on Histologic and biomechanical tendon-bone interface healing and fatty infiltration. High-dose atorvastatin did not impair histologic and biomechanical healing of the tendon-bone interface and significantly inhibited the expression of the muscle atrophy marker MuRF-1 (P < .001).