Key result
Young patients with thalassemia major in a preclinical stage of heart disease had significantly lower mean 24-h ambulatory blood pressure and abnormal heart rate rhythms than controls (P<0.05).
Why the study?
Are 24-h blood pressure and heart rate profiles and sympathovagal interaction altered in young patients with thalassemia major compared to healthy controls?
Population
18 subjects: 9 beta-thalassemic patients without clinical signs of cardiac failure and 9 age- and…
Design
Case-control
Follow-up
24 hours
Authors
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Impaired 24-h BP/HR variability may signal preclinical autonomic dysfunction in TM; leaves open whether these measures predict cardiac progression.
Case-Control (n=18)
Are 24-h blood pressure and heart rate profiles and sympathovagal interaction altered in young patients with thalassemia major compared to healthy controls?
p-value: p=<0.05
Young patients with thalassemia major in a preclinical stage of heart disease exhibit abnormal 24-h BP and HR rhythms and decreased short-term variability, indicating diminished sympathetic activity.
Franco Veglio (1998) conducted a case-control in Thalassemia major (n=18). Thalassemia major vs. Age- and sex-matched controls was evaluated on 24-h ambulatory blood pressure and heart rate variability (p=<0.05). Young patients with thalassemia major in a preclinical stage of heart disease had significantly lower mean 24-h ambulatory blood pressure and abnormal heart rate rhythms than controls (P<0.05).
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