Key result
Serum concentrations of sTNFR1 and sTNFR2 were independently associated with arterial stiffness measured by baPWV (β = 0.316, P < 0.001 and β = 0.235, P = 0.005, respectively).
Why the study?
Are serum concentrations of sTNFR1 and sTNFR2 associated with arterial stiffness (baPWV) in patients with suspected coronary artery disease?
Cross-Sectional (n=117)
Are serum concentrations of sTNFR1 and sTNFR2 associated with arterial stiffness (baPWV) in patients with suspected coronary artery disease?
Effect estimate: sTNFR1: β = 0.316; sTNFR2: β = 0.235
p-value: p=<0.001 and 0.005
Serum levels of sTNFR1 and sTNFR2 are independently associated with arterial stiffness in patients with suspected coronary artery disease, highlighting a link between inflammation and vascular stiffening.
sTNFRs were associated with arterial stiffness in suspected CAD; leaves open causal role or therapeutic targeting.
BACKGROUND: Soluble forms of tumor necrosis factor receptors (sTNFRs) are emerging target molecules of inflammatory disease. However, their role in vascular biology is not well known. This study was performed to investigate the association between serum concentrations of sTNFRs and arterial stiffness. METHODS: A total of 117 consecutive patients with suspected coronary artery disease (CAD) (63.6 ± 11.0 years; men, 65%) who were referred for invasive coronary angiography (ICA) were prospectively enrolled. Arterial blood sTNFR1 and sTNFR2 were measured using commercially available ELISA kits. Brachial-ankle pulse wave velocity (baPWV) measurements were made within 24 hours of blood sampling for sTNFRs measurement. RESULTS: Most of the patients (86.3%) had significant CAD (stenosis ≥ 50%) in ICA. In simple linear regression analyses, there were significant positive correlations of baPWV with sTNFR1 (r = 0.483, P < 0.001) and sTNFR2 (r = 0.366, P < 0.001). In multiple linear regression analyses, sTNFR1 (β = 0.316, P < 0.001) and sTNFR2 (β = 0.235, P = 0.005) had independent association with baPWV even after controlling for potential confounders. CONCLUSION: sTNFR1 and sTNFR2 were independently associated with baPWV in patients undergoing ICA. This result may extend previous knowledge on close interactions between inflammation and arterial stiffening.
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Kim et al. (2016) conducted a cross-sectional in Suspected coronary artery disease (CAD) (n=117). Serum concentrations of sTNFR1 and sTNFR2 was evaluated on Brachial-ankle pulse wave velocity (baPWV) (sTNFR1: β = 0.316; sTNFR2: β = 0.235, p=<0.001 and 0.005). Serum concentrations of sTNFR1 and sTNFR2 were independently associated with arterial stiffness measured by baPWV (β = 0.316, P < 0.001 and β = 0.235, P = 0.005, respectively).
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