Key result
Electrical storm linked to ~4.7-fold higher periprocedural mortality during ventricular tachycardia ablation.
Why the study?
Catheter ablation is established for VT, but the impact of electrical storm on ablation outcomes remains uncertain.
Does electrical storm worsen periprocedural and long-term outcomes in patients undergoing catheter ablation for ventricular tachycardia?
Meta-Analysis (n=3,531)
Yes
Does electrical storm worsen periprocedural and long-term outcomes in patients undergoing catheter ablation for ventricular tachycardia?
While catheter ablation for VT in patients with electrical storm has similar acute procedural success to those without, it is associated with significantly higher early and long-term mortality and VT recurrence.
Answers are grounded in this paper and cite their sources.
Electrical storm signals markedly higher periprocedural mortality risk in VT ablation; extends observational evidence supporting intensified periprocedural monitoring.
Background Electrical storm (ES) is a life‐threatening manifestation of ventricular tachycardia (VT) associated with highmorbidity and mortality. Catheter ablation is an established therapy for VT, but the impact of ES on ablation outcomes remains uncertain. Methods We conducted a systematic review and meta‐analysis in accordance with PRISMA 2020 to compare VT ablation outcomes in patients with and without ES. PubMed, Cochrane Library, and ScienceDirect were searched from inception through January 2026. Eligible studies were comparative cohorts reporting periprocedural or long‐term outcomes. Random‐effects models were used to pool odds ratios (ORs), hazard ratios (HRs), and mean differences (MDs), with heterogeneity assessed using the I 2 statistic. Results Six observational cohort studies including 3531 patients (1183 with ES and 2348 without ES) were included. Acute procedural endpoints, including post‐ablation VT non‐inducibility and residual inducible VT, were similar between groups. Periprocedural or in‐hospital mortality was significantly higher in the ES group (OR 4.71, 95% CI 2.76–8.06), whereas complication rates, procedural duration, radiofrequency ablation time, and need for hemodynamic support did not differ significantly. During follow‐up, ES was associated with higher all‐cause mortality (OR 1.67, 95% CI 1.19–2.35) and greater VT recurrence in both arm‐based (OR 1.45, 95% CI 1.11–1.91) and time‐to‐event analyses (HR 1.35, 95% CI 1.16–1.57). Conclusions VT ablation showed comparable acute procedural success and procedural safety in patients with and without ES. However, ES was associated with higher early and long‐term mortality and greater VT recurrence, supporting its role as a marker of adverse prognosis.
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Jalil et al. (2026) conducted a meta-analysis in Ventricular Tachycardia (n=3,531). Electrical storm vs. Non-electrical storm was evaluated on Periprocedural or in-hospital mortality (OR 4.71, 95% CI 2.76-8.06, p=<0.0001). Electrical storm was associated with significantly higher periprocedural or in-hospital mortality (OR 4.71) compared to non-electrical storm in patients undergoing ventricular tachycardia ablation.
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