Answers are grounded in this paper and cite their sources.
Background: Multiple sclerosis (MS) is one of the most common diseases of the nervous system, characterized by inflammation of the central nervous system and oxidative stress. Carvacrol is a monoterpenoid phenol with antioxidant effects against free radical. The aim of this study was to evaluate the effect of carvacrol on the expression of Hmox-1, iNOS, Nrf2 and NF-B genes in the spinal cord of Experimental Autoimmune Encephalomyelitis (EAE) rats as an animal model of MS. Materials and Methods: EAE was induced in female Lewis rats and they were then divided into three groups: control, EAE model, and EAE treated with carvacrol. Carvacrol was daily injected intraperitoneally for 17 days after immunization. RNA was extracted from rat spinal cord tissue and changes in the expression of the Hmox-1, iNOS, Nrf2 and NF-B genes were examined by Real-Time PCR.
No takes yet. Share an insight, caveat, or question.
Ahmadi et al. (2022) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: