Key result
Induced right bundle branch block in dogs demonstrated that the Purkinje network does not participate in normal fashion in endocardial spread of the excitation impulse.
Why the study?
How does right bundle branch block alter the endocardial spread of the excitation impulse in the right ventricle?
How does right bundle branch block alter the endocardial spread of the excitation impulse in the right ventricle?
Experimental right bundle branch block in dogs demonstrates that the Purkinje network does not participate normally in the endocardial spread of the excitation impulse.
Answers are grounded in this paper and cite their sources.
Experimental RV activation patterns after RBBB in dogs leave open Purkinje contributions in humans; translational studies required.
Right bundle branch block was produced in dogs, and activation of the free wall of the right ventricle was studied by means of multipolar electrodes. After block, accession spread radially at the earliest activated endocardial point and tangentially at later activated points. Direct current stimulation of selected endocardial points resulted in patterns of activation resembling those obtained after right bundle branch block in controls and after block. It is concluded that the Purkinje network does not participate in normal fashion in endocardial spread of the excitation impulse after right bundle branch block.
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Conrad et al. (1959) studied Right bundle branch block. Induced right bundle branch block vs. Controls (before block) was evaluated on Activation patterns of the free wall of the right ventricle. Induced right bundle branch block in dogs demonstrated that the Purkinje network does not participate in normal fashion in endocardial spread of the excitation impulse.
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