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Compound 27k, a novel ebselen derivative, is a potent covalent inhibitor of NDM-1 that restores the efficacy of meropenem against NDM-1-producing bacteria in vitro and in vivo by forming a Se-S covalent bond with the NDM-1 protein. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Structure-DirectedOptimization of Ebselen Derivativesas Potent NDM-1 Inhibitors Reverses Meropenem Resistance

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