Key result
An elevated triglyceride-glucose index independently predicted a higher risk of acute kidney injury in critically ill patients with atrial fibrillation, with the highest tertile showing an OR of 1.37 compared to the lowest.
Why the study?
Atrial fibrillation is common in intensive care and often complicated by acute kidney injury, but the triglyceride-glucose index had not been evaluated for AKI risk in this population.
Does an elevated triglyceride-glucose (TyG) index predict acute kidney injury in critically ill patients with atrial fibrillation?
Cohort (n=1,142)
No
Does an elevated triglyceride-glucose (TyG) index predict acute kidney injury in critically ill patients with atrial fibrillation?
Answers are grounded in this paper and cite their sources.
An elevated triglyceride-glucose index independently predicts a higher risk of acute kidney injury in critically ill patients with atrial fibrillation, offering a potential tool for risk stratification.
BACKGROUND: Atrial fibrillation (AF) is common in intensive care and often complicated by acute kidney injury (AKI). The triglyceride-glucose (TyG) index, a marker of insulin resistance, has not been studied for AKI risk in AF patients. METHODS: This retrospective cohort study analyzed 1,142 critically ill AF patients from MIMIC-IV. Patients were stratified by TyG index tertiles. Multivariable logistic regression, restricted cubic splines, and ROC curves assessed the TyG-AKI relationship, adjusting for confounders. RESULTS: AKI incidence was highest in the top TyG tertile (52.76%) versus middle (37.20%) and lowest (36.39%) (p < 0.001). After adjustment, higher TyG (continuous) correlated with increased AKI risk (OR 1.21, 95% CI 1.02-1.45, p = 0.002). The highest tertile had greater AKI risk than the lowest (OR 1.37, 95% CI 1.29-2.02, p = 0.02). Spline analysis showed a near-linear dose-response relationship. The ROC AUC was 0.77, indicating moderate predictive value. Subgroup analyses confirmed consistency across age, sex, ethnicity, and comorbidities. CONCLUSION: Elevated TyG index independently predicts higher AKI risk in critically ill AF patients, with a near-linear association. The TyG index may aid AKI risk stratification in this population.
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Lu et al. (2025) conducted a cohort in Atrial fibrillation in critically ill patients (n=1,142). Elevated triglyceride-glucose (TyG) index vs. Lowest tertile of triglyceride-glucose (TyG) index was evaluated on Acute kidney injury (AKI) (OR 1.37, 95% CI 1.29-2.02, p=0.02). An elevated triglyceride-glucose index independently predicted a higher risk of acute kidney injury in critically ill patients with atrial fibrillation, with the highest tertile showing an OR of 1.37 compared to the lowest.
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