Key result
In 11 patients with end-stage diabetic kidney disease, neuromuscular electrical stimulation during hemodialysis significantly lowered mean blood glucose levels and glycemic excursion compared to rest.
Why the study?
Hemodialysis patients with diabetic kidney disease experience blood glucose fluctuations owing to insulin removal, but the effects of neuromuscular electrical stimulation during hemodialysis on glycemic control were not evaluated.
Does neuromuscular electrical stimulation during hemodialysis improve glycemic control in outpatients with end-stage diabetic kidney disease?
RCT (n=11)
Does neuromuscular electrical stimulation during hemodialysis improve glycemic control in outpatients with end-stage diabetic kidney disease?
Answers are grounded in this paper and cite their sources.
Neuromuscular electrical stimulation during hemodialysis acutely decreases blood glucose levels and glycemic excursions in patients with end-stage diabetic kidney disease.
Hemodialysis patients with diabetic kidney disease (DKD) experience blood glucose fluctuations owing to insulin removal. We evaluated the effects of single and long-term application of neuromuscular electrical stimulation (NMES) during hemodialysis on glycemic control. This trial was conducted in two stages: Stage 1, following a crossover design and 4 week washout period, eleven outpatients with DKD either underwent a single bout of NMES for 30 min (NMES period) or rested (control period) after receiving nutritional support during hemodialysis; Stage 2, following a crossover design and 4 week washout period, each participant received the intervention for 12 weeks. NMES was administered for 30 min at the maximum tolerable intensity. The mean subcutaneous glucose concentration and mean amplitude of glycemic excursion (MAGE) were determined by flash glucose monitoring for 24 h. Changes in glycoalbumin and MAGE before and after NMES initiation were evaluated. The mean blood glucose level and MAGE after a single bout of NMES were significantly lower than those after rest. Glycoalbumin levels and echo intensity of the rectus femoris tended to decrease, but not significantly by ANOVA due to a lack in statistical power after the dropout of three patients. NMES in end-stage DKD decreased blood glucose levels during and after hemodialysis.
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Tsurumi et al. (2022) conducted an RCT in End-Stage Diabetic Kidney Disease (n=11). Neuromuscular electrical stimulation (NMES) vs. Rest was evaluated on Mean subcutaneous glucose concentration and mean amplitude of glycemic excursion (MAGE). In 11 patients with end-stage diabetic kidney disease, neuromuscular electrical stimulation during hemodialysis significantly lowered mean blood glucose levels and glycemic excursion compared to rest.
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