Evaluating Low Values of Early Diastolic Velocity (e’) as a Predictor of Major Cardiovascular Events in Patients with Acute Myocardial Infarction

Background: Effective risk stratification is an integral part of acute myocardial infarction (AMI) management. Meanwhile, the stratification system should be performed by using easy instruments or methods, where appropriate management, intervention timing, and prognosis can be determined. A previous study established acute ischemia implicate the diastolic function of the left ventricle. In this situation, echocardiography is an easy-to-use and effective diagnostic tool. Therefore, this study evaluates left ventricular diastolic function using the tissue Doppler imaging (TDI) method to analyze the reduction of early diastolic velocity (e’) as a predictor for numerous cardiovascular events in patients with AMI. Method: The study design was an observational study with a prospective cohort design. The data for the septal and lateral Early Diastolic Velocities (e’) was acquired using the transthoracic echocardiography procedure on AMI patients. The Hazard Ratio (HR) and survival curve from prognostic factors of major adverse cardiovascular events were also produced. Results: There were 66 patients diagnosed with AMI. The median was 6.625cm/s, and the cut-off point was to determine the decreasing or abnormal mean e’. Subsequently, this value at RR 2.8 was shown by the multivariate analysis via Cox regression as an independent factor of major adverse cardiovascular events. Conclusion: Decreased means e’ has been proven as an independent predictor of major adverse cardiovascular events in hospitalized patients with AMI.