The covalent immobilization of antibodies using non-amphiphilic alkylated cellulose films is described—the Figure shows the antibodies attached to the film via imino bonds. Rapid detection of a specific antibody–antigen reaction is demonstrated as is single-molecule detection. Thus biochemical surfaces prepared in this way have great potential as ultrasensitive bio- and immunosensors.
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Löscher et al. (1998) studied this question.
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