Key result
The Na+/H+ exchanger plays a crucial role in protecting cells from intracellular acidification, but its activation during recovery from ischemia may contribute to calcium overload and reperfusion injury in the myocardium.
Authors
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Potential NHE inhibition target in reperfusion injury; leaves open clinical translation pending trials.
Fliegel et al. (1993) conducted a review in Intracellular pH regulation and cardiac physiology. Na+/H+ exchanger was evaluated. The Na+/H+ exchanger plays a crucial role in protecting cells from intracellular acidification, but its activation during recovery from ischemia may contribute to calcium overload and reperfusion injury in the myocardium.