Deep brain stimulation (DBS) is a promising treatment option for severe refractory major depressive disorder (MDD) [1,2]. The most common neural targets for DBS in MDD are the subcallosal cingulate cortex (SCC) and the ventral capsule/ventral striatum (VC/VS) [3–5]. The long-term clinical response after DBS to these targets has been characterized as a gradual improvement in mood, with >40% of patients reaching a responder status by 1 year [3,4].
No takes yet. Share an insight, caveat, or question.
Davidson et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: