Key result
Hancock valve replacement was associated with a low risk of thromboembolic complications in aortic and stable mitral patients, though mitral patients with atrial fibrillation had an increased risk.
Why the study?
What is the incidence of thrombotic and thromboembolic complications after Hancock porcine heterograft valve replacement, and how does it vary by valve position and antithrombotic therapy?
Population
290 patients who underwent Hancock porcine heterograft valve replacement
Comparison
Antithrombotic therapy regimens vs null
Design
Cohort
Authors
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May guide anticoagulation in Hancock recipients; leaves open randomized confirmation in mitral AF.
Cohort (n=290)
What is the incidence of thrombotic and thromboembolic complications after Hancock porcine heterograft valve replacement, and how does it vary by valve position and antithrombotic therapy?
Patients with Hancock aortic valves or stable mitral valves in sinus rhythm have low thromboembolic risk and may not require anticoagulation, whereas those with mitral valves and atrial fibrillation require warfarin for 3 months followed by aspirin.
Hetzer et al. (1979) conducted a cohort in Mitral or aortic valve prostheses (n=290). Hancock valve replacement was evaluated on Thrombotic and thromboembolic (TE) complications. Hancock valve replacement was associated with a low risk of thromboembolic complications in aortic and stable mitral patients, though mitral patients with atrial fibrillation had an increased risk.
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