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Flexing your bipheps: Enantioselective propargylic substitution reactions of propargylic acetates with amines catalyzed by a copper-(R)-Cl-MeO-biphep or -binap complex give the corresponding propargylic amines in excellent yields with up to 89 % ee. The reaction described may provide a novel synthetic method for the preparation of chiral propargylic amines.
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Hattori et al. (2008) studied this question.
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