This method demonstrates the efficient synthesis of 4-arylpiperidines in a safer process involving zinc activation.
A general procedure for the synthesis of 4-arylpiperidines via the coupling of 4-(N-BOC-piperidyl)zinc iodide with aryl halides and triflates is presented. The reaction requires cocatalysis with both Cl(2)Pd(dppf) and a copper(I) species. An improved, safer procedure for the activation of zinc dust is also presented.
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Corley et al. (2004) studied this question.
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