Key result
Oral clonidine reduced heart rate to <100 beats/min in 8 of 9 patients vs 2 of 9 controls, with a mean heart rate decrease difference of 38 beats/min (95% CI, 20-56).
Why the study?
Does oral clonidine reduce ventricular rate in hemodynamically stable patients with rapid atrial fibrillation?
Population
18 hemodynamically stable patients evaluated or treated for rapid atrial fibrillation in a university…
Comparison
Clonidine 0.075 mg orally at baseline, and after… vs No treatment
Design
RCT, Randomly assigned
Follow-up
4 hours
Authors
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Supports clonidine as an alternative for rate control in stable rapid AF; extends RCT evidence for nonstandard agents when beta-blockers or calcium-channel blockers are contraindicated.
RCT (n=18)
No
Does oral clonidine reduce ventricular rate in hemodynamically stable patients with rapid atrial fibrillation?
Mean Difference: 38 (95% CI 20–56)
Low-dose oral clonidine effectively and safely reduced ventricular rate in hemodynamically stable patients with rapid atrial fibrillation in the emergency department.
Roth et al. (1992) conducted an RCT in rapid atrial fibrillation (n=18). Clonidine vs. no treatment was evaluated on Mean decrease in heart rate (MD 38 beats/min, 95% CI 20 to 56). Oral clonidine reduced heart rate to <100 beats/min in 8 of 9 patients vs 2 of 9 controls, with a mean heart rate decrease difference of 38 beats/min (95% CI, 20-56).
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