Key result
Ponatinib treatment in a 56-year-old male with chronic myeloid leukemia led to acute heart failure and non-ischemic dilated cardiomyopathy, which improved after treatment interruption.
Why the study?
Despite its efficacy in acute and chronic leukemia, ponatinib may cause cardiovascular adverse effects.
Does ponatinib treatment cause acute heart failure in patients with chronic myeloid leukemia?
Case Report (n=1)
Does ponatinib treatment cause acute heart failure in patients with chronic myeloid leukemia?
Ponatinib therapy can induce acute heart failure and non-ischemic dilated cardiomyopathy, which may be reversible upon drug discontinuation, necessitating close cardiovascular monitoring.
Ponatinib is a third-generation tyrosine kinase inhibitor with potent efficacy in the treatment of acute and chronic leukemia. Despite having an effective and sustained activity in all BCR-ABL1 mutations, it may cause cardiovascular adverse effects. Here we report a 56-year-old male patient with Chronic myeloid leukemia and no prior cardiac disorder who developed acute heart failure under ponatinib treatment. Guideline-recommended medical treatment for heart failure was initiated. Coronary angiography to exclude ischemic heart disease revealed no coronary stenosis. Cardiac magnetic resonance imaging showed findings consistent with non-ischemic dilated cardiomyopathy. After interruption of ponatinib treatment, cardiac evaluation showed improvement in left ventricular ejection fraction. Patients on Ponatinib therapy should be closely monitored for signs and symptoms of heart failure.
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Tokatlı et al. (2023) conducted a case report in Chronic myeloid leukemia (n=1). Ponatinib was evaluated on Development of acute heart failure and non-ischemic dilated cardiomyopathy. Ponatinib treatment in a 56-year-old male with chronic myeloid leukemia led to acute heart failure and non-ischemic dilated cardiomyopathy, which improved after treatment interruption.
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