Key result
Heterologous expression of the human hHCN4 channel produced unusually slow kinetics of activation and inactivation, with a mean potential of half-maximal activation of -75.2 mV.
Population
Human hHCN4 transcripts and heterologous expression system
Design
Preclinical
Authors
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hHCN4 adds a cardiac-expressed isoform to the HCN family; leaves open its specific roles in human rhythm control.
The molecular and functional characterization of the human hHCN4 channel reveals its slow gating properties and predominant expression in the thalamus and heart, suggesting a key role in controlling rhythmic pacemaker activity.
Seifert et al. (1999) studied this question. hHCN4 channel expression was evaluated on Mean potential of half-maximal activation (V(1/2)). Heterologous expression of the human hHCN4 channel produced unusually slow kinetics of activation and inactivation, with a mean potential of half-maximal activation of -75.2 mV.
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