Key result
Pre-eclampsia and gestational hypertension were associated with markedly and mildly elevated central augmentation pressure and augmentation index, respectively, compared to normal pregnancy.
Why the study?
Does radial artery applanation tonometry discriminate between normal pregnancy, gestational hypertension, and pre-eclampsia in third-trimester women?
Observational (n=99)
No
Does radial artery applanation tonometry discriminate between normal pregnancy, gestational hypertension, and pre-eclampsia in third-trimester women?
Non-invasive applanation tonometry can discriminate between normal pregnancy, gestational hypertension, and pre-eclampsia, suggesting potential utility in predicting pre-eclampsia.
Applanation tonometry may discriminate third-trimester hypertensive disorders; leaves open predictive utility and requires prospective validation.
OBJECTIVE: To compare peripheral pulse pressure waveforms in normal pregnancy, gestational hypertension (GH) and pre-eclampsia (PE). DESIGN: Comparative study. SETTING: Tertiary referral teaching hospital. SAMPLE: Women with hypertensive disease in pregnancy and matched normal pregnant controls. METHODS: Women in the third trimester of pregnancy with newly developed PE (n= 27) or GH (n= 33) were studied by radial artery applanation tonometry. Values were compared with those for gestational age matched normal pregnant women (n= 39). MAIN OUTCOME MEASURES: Augmentation Index. RESULTS: Hypertension was of equal severity in PE and GH. Central augmentation pressure and augmentation index, indicating vasoconstriction, were mildly elevated in GH, but markedly elevated in PE. CONCLUSION: Non-invasive applanation tonometry discriminates among normal pregnancy, GH and PE, and may be useful to predict PE.
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Spasojevic et al. (2005) conducted an observational in Pre-eclampsia and gestational hypertension (n=99). Pre-eclampsia and gestational hypertension vs. Normal pregnancy was evaluated on Augmentation Index. Pre-eclampsia and gestational hypertension were associated with markedly and mildly elevated central augmentation pressure and augmentation index, respectively, compared to normal pregnancy.
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