Key result
Kuwaiti cohort reveals distinct warfarin response variants across CYP2A7, CYP4F2, and VKORC1.
Observational (n=1,395)
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Assessing the distinct prevalence or absence of genetic variants associated with differential response to the anticoagulant medication of warfarin in different population groups is actively pursued by pharmacogenomics community. Populations from Arabian Peninsula are underrepresented in such studies. By way of examining exome- and genome-wide genotype data from 1395 Arab individuals in Kuwait, we report distinct occurrence of warfarin response-related variants rs12460590_A/CYP2A7, rs2108622_T/CYP4F2, rs2884737_C/VKORC1 and distinct absence of rs11150606_C/PRSS53 in Kuwaiti population. The presented results in conjunction with similar literature reports on Qatari population enhance the worldwide understanding on population-specific distributions of genetic variants associated with warfarin drug dosage.
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John et al. (2017) conducted an observational in Warfarin dosage genetic variants (n=1,395). Warfarin response-related genetic variants was evaluated on Occurrence or absence of warfarin response-related genetic variants. Analysis of 1,395 Kuwaiti individuals revealed distinct occurrence of warfarin response variants in CYP2A7, CYP4F2, and VKORC1, and absence of the PRSS53 variant.
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