Key result
Epileptic seizures trigger autonomic cardiac dysregulation, frequently provoking arrhythmogenic events that drive SUDEP risk.
Why the study?
How do epileptic seizures influence heart rhythm and conduction, and what is their role in sudden unexpected death in epilepsy (SUDEP)?
How do epileptic seizures influence heart rhythm and conduction, and what is their role in sudden unexpected death in epilepsy (SUDEP)?
Highlights the critical importance of recognizing epilepsy-induced autonomic dysregulation and cardiac arrhythmias to understand and potentially mitigate the risk of sudden unexpected death in epilepsy (SUDEP).
Epileptic seizures affect the heart function and can provoke heart rhythm abnormalities and conduction disorders. Dysfunctions of the supra-segmental vegetative structures are thought to play a significant role in the development of arrhythmic syndrome in epilepsy. The asymmetric influence of the left and right cerebral hemispheres on the heart rate, the impact of antiepileptic drugs and other factors on the heart rhythm are still under discussion. The role of heart rhythm abnormalities in the pathogenesis of sudden unexplained death in epilepsy is also reviewed here. We analyze the pathogenesis of cardiac arrhythmias in epilepsy, the occurrence and risk factors, the types of disorders, the role of antiepileptic therapy and the significance of cardiac arrhythmias for the development of sudden death in patients with epilepsy (SUDEP).
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Rubleva et al. (2018) conducted a review in Epilepsy and associated cardiac arrhythmias. Epileptic seizures was evaluated. Epileptic seizures significantly affect autonomic cardiac regulation, frequently provoking heart rhythm abnormalities such as ictal tachycardia, bradycardia, or asystole, which play a major role in the pathogenesis of sudden unexpected death in epilepsy (SUDEP).
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