Key result
Sweep gas flows of 1.60 and 2.0 l/min/m2 during cardiopulmonary bypass significantly decreased pCO2 compared to 1.35 l/min/m2 (P<0.02), with 2.0 l/min/m2 causing profound hypocapnia and alkalosis.
Why the study?
Does higher sweep gas flow (1.60 or 2.0 l/min/m2) compared to 1.35 l/min/m2 alter pCO2 and pH levels during cardiopulmonary bypass in patients undergoing CABG?
Population
30 patients undergoing isolated coronary artery bypass grafting (CABG)
Comparison
Sweep gas flow to oxygenator at 1.60 l/min/m2 or… vs Sweep gas flow to oxygenator at 1.35 l/min/m2…
Design
RCT, randomly and equally allocated into three groups
Follow-up
end of rewarming period during cardiopulmonary bypass
Authors
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Target sweep gas flow at 1.35-1.60 l/min/m² during CPB to avoid hypocapnia and alkalosis; RCT extends perfusion parameter guidance in CABG.
RCT (n=30)
randomly and equally allocated
Does higher sweep gas flow (1.60 or 2.0 l/min/m2) compared to 1.35 l/min/m2 alter pCO2 and pH levels during cardiopulmonary bypass in patients undergoing CABG?
p-value: p=<0.02
Sweep gas flow to the oxygenator during cardiopulmonary bypass should be kept between 1.35 and 1.60 l/min/m2 to avoid hypocapnia and alkalosis.
Karabulut et al. (2002) conducted an RCT in isolated CABG (n=30). Sweep gas flow to oxygenator vs. 1.35 l/min/m2 was evaluated on pCO2 levels 5 minutes after initiation of CPB (p=<0.02). Sweep gas flows of 1.60 and 2.0 l/min/m2 during cardiopulmonary bypass significantly decreased pCO2 compared to 1.35 l/min/m2 (P<0.02), with 2.0 l/min/m2 causing profound hypocapnia and alkalosis.
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