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February 1, 2003Journal of Biological ChemistryOpen Access

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

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Authors

NINaohiro InoharaUniversity of MichiganYOYasunori OguraNara Women's UniversityAFAna FontalbaMarqués de Valdecilla University Hospital

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Implication

Randomized trial examines NOD2’s role in recognizing muramyl dipeptide, suggesting implications for Crohn's disease and vaccine development.

Key Points

  • The study aims to identify the structural components of bacterial peptidoglycan recognized by NOD2 and its relevance to Crohn's disease.
  • Biochemical analyses were conducted to identify the structure of muramyl dipeptide.
  • Functional assays assessed NOD2 response to variants of muramyl dipeptide.
  • Peripheral blood mononuclear cells were tested for their response to lipopolysaccharide and synthetic muramyl dipeptide.
  • Muramyl dipeptide was confirmed as the recognized moiety by NOD2, with stereoselective recognition demonstrated.
  • NOD2 mutations linked to Crohn's disease exhibited impaired recognition of muramyl dipeptide.
  • Cells from individuals with the L1007fsinsC NOD2 mutation responded to lipopolysaccharide but not to synthetic muramyl dipeptide.

Cite This Study

Inohara et al. (2003) studied this question.

synapsesocial.com/papers/6a6a8a4426cff2e2f6f414e9https://doi.org/10.1074/jbc.c200673200
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