Key result
Patients with severe hypertriglyceridemia were 5.77 times more likely to carry genetic susceptibility variants compared with controls (OR 5.77; 95% CI 4.26-7.82; P<0.0001).
Why the study?
What are the genetic determinants and molecular contributors of severe hypertriglyceridemia?
Cohort (n=563)
What are the genetic determinants and molecular contributors of severe hypertriglyceridemia?
Odds Ratio: 5.77 (95% CI 4.26–7.82)
p-value: p=<.0001
Severe hypertriglyceridemia is predominantly a polygenic trait rather than a monogenic disorder, with nearly half of patients exhibiting high polygenic risk.
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Supports polygenic basis of severe hypertriglyceridemia; leaves open whether genetic testing improves risk stratification or management.
Dron et al. (2018) conducted a cohort in Severe hypertriglyceridemia (n=563). Genetic susceptibility variants vs. Controls was evaluated on Carrying genetic susceptibility variants (OR 5.77, 95% CI 4.26-7.82, p=<.0001). Patients with severe hypertriglyceridemia were 5.77 times more likely to carry genetic susceptibility variants compared with controls (OR 5.77; 95% CI 4.26-7.82; P<0.0001).
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