The deprotonation of the zinc-bound water and the zinc-bound bicarbonate which arose from hydration of CO2 have been simulated in vitro according to the proposed mechanism for carbonic anhydrase, with the model complex of its own active site, [LZn(OH2)]2+, where L = tris(2-benzimidazolylmethyl)amine.
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Nakata et al. (1997) studied this question.
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